The cause of ovarian cancer is multifactorial. The first theory to explain the minor trauma that takes place continuously during the ovulatory cycle (egg expenditure cycle each month), the second theory to explain about the exposure of the ovaries to gonadotropin hormone may increase the risk of malignancy. The third theory about the carcinogens (substances that can stimulate the occurrence of malignancy) may come into contact with the ovary through the reproductive tract. karsigonik substances are strongly associated with a person's risk for cancer, especially ovarian cancer has been reported is Acrylamide (Larsson et al., 2009).
Acrylamide is a simple organic compound with chemical formula C5H5NO. In pure form, tangible and odorless white crystal, easily soluble in water, ethanol, ether or chloroform, easy to decompose into ammonia, nitrogen oxides, carbon dioxide and carbon monoxide. Acrylamide ketubuh enter through the air (inhaled) or imbibition through the skin, usually for people who deal directly with Acrylamide for example the job. But in general, can enter the human body through water and food intake (WHO, 2005).
Through the water. because of the nature of Acrylamide which can thicken the liquid so widely used for wastewater treatment. Waste that is clean and then channeled to the reservoir tanks, then into a river. Waste which may still contain Acrylamide is partly absorbed into the ground and mixed with ground water to then enter into the well. Some were thrown into rivers or the sea. As you know, some of our communities, even companies, water utilities, especially major cities still use the river to meet their water needs (WHO, 2005).
Through food. Acrylamide compounds can be formed on a high carbohydrate foods such as corn, potatoes, cassava, and other tepung2an others, who in a presentation in fried, grilled or baked at temperatures above 120 degrees Celsius. Some foods such as potato chips or products made from potatoes such as french fries, cereal (breakfast products), produk2 bakery (baked bread), and produk2 made from corn or corn flour are believed to produce the Acrylamide in processing because it is generally in the presentation require high temperature and long enough, especially if it changes color to brown (overcooked) or scorched.
Coffee. In fact, coffee or chocolate is a source of Acrylamide, not at the time of presentation (brewed with hot water), but at the time of manufacturing process from raw materials (coffee beans) that are baked or disangan. Acrylamide concentration in the coffee is not too high, but for serious coffee lovers who drink coffee 3 or 4 times a day, then the accumulation of so many.
Acrylamide In the body detoxified by glutathione conjugation becomes marcaptures in urine. Another pathway that is metabolized into glysidamide Acrylamide by enzyme CYP2E1. Next glysidamide in metabolism become glyceramide by enzyme epoxide hydrolase (EPHX1), which in turn could dieksresikan with urine. But glyceramide can bind to DNA-GA-DNA adducts that can trigger cancer. Also glysidamide Acrylamide and can bind to hemoglobin (Hege et al., 2007; Fennell et al. 2005; Besaratinia et al., 2007).